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MPO mediates the vascular inflammation that propagates plaque development and activates protease cascades which might be linked to plaque vulnerability. White blood mobile activation in the bloodstream, in reaction to luminal harm of your artery wall including fissures, erosions or simply a degrading collagen cap, leads to MPO release during the bloodstream.
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This mixture of detrimental effects demonstrates that MPO is actively associated with the progression of atherosclerosis.
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